Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretic...

Multiple sclerosis: immunologic aspects.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Although the causes are not known, the pathogenesis likely involves complex relationships between autoimmunity, immunogenetics, immunologic deficiency and viral infection. The evidence for such interrelationships is discussed.

Lactoferrin and immunologic dissonance: clinical implications.

Homeostasis is the maintenance of equilibrium in a biological system by means of positive and negative feedback control mechanisms that counteract influences tending toward physiological dissonance. At the molecular level, homeostasis is controlled by the network of the neuro-endocrine-immune system, in which lactoferrin (LF) plays a central role. The purpose of this review is to provide a comp...

Post-transfusion purpura: immunologic aspects and therapy.

Immunologic differences in human isoferritins: implications for immunologic quantitation of serum ferritin.

Immunologic differences in several tissue isoferritin populations have been investigated using antibodies developed in rabbits against human liver ferritin and in guinea pigs against HeLa cell ferritin. Our results indicate that the quantity of ferritin measured by radioimmunoassays is markedly affected by the isoferritin and subunit composition of the ferritin sample as well as by the nature o...